Deciphering Molecular Orchestrations: XooClp Integrates Environmental Sensing and Virulence Regulation in Xanthomonas oryzae pv. oryzae

It is important for bacterial pathogens to precisely detect diverse environmental cues and merge these signals to generate a coordinated response that sustains growth and establishes virulence. This is carried out by multiple receptor proteins on the membrane, small molecules that respond to changes in receptor status, and transcription factors that bind these small molecules and regulate the expression of specific genes. It is essential to understand how this complex orchestration of events happens at the molecular level, in order to gain mechanistic insights into the survival and virulence of these pathogens.